pone.0297493.g009.tif (662.55 kB)
The interactions of TMP and PLU (N = 3), indicate indifference between the two agents.
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posted on 2024-01-26, 18:35 authored by Songtao Bie, Qiuyue Mo, Chen Shi, Hui Yuan, Chunshuang Li, Tong Wu, Wenlong Li, Heshui Yu(A) Single-agent dose-response curve for TMP; (B) Single-agent dose-response curve for PLU; (C) The interaction landscape of the combinations of TMP and PLU; (D) Synergy scores were calculated by the Bliss independence model and were colored when significant. A detailed description of the various plots is given in Fig 4. Raw data of these experiments can be found in (S2 File). TMP: trimethoprim, PLU: plumbagin.
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exploring alternative sourcesbliss independent modelnit ), ciprofloxacinexhibits antibacterial activitycpr ), mecillinamsevere clinical infectionsresponse surface analysispromising antimicrobial agentminimum inhibitory concentrationselected five antibioticsfive common antibioticsvitro antibacterial activityspecific dose regionstaphylococcus aureus inhibitory activitystaphylococcus aureusmec ),vitro severe situationresponse matrixantimicrobial spectruminhibitory activitiesaureus existing antibioticssignificant synergypresent studymain culpritimproved approachentire doseeffective strategiesdifferent mechanismsdemonstrated acrosschl ).antibiotic resistance73 μg4 μg
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