pone.0296925.g003.tif (4.28 MB)
The immunohistochemical staining using antibodies against PTPN2, PTPN13, DHCR24 (Seladin), and PIK3R2 in representative gingival biopsies from the HH, HP, DH, and DP groups.
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posted on 2024-01-19, 18:51 authored by Poliana Mendes Duarte, Bruno César de Vasconcelos Gurgel, Tamires Szeremeske Miranda, Juliana Sardenberg, Tongjun Gu, Ikramuddin AukhilBar length = 50 μm, original magnification × 20. HH: non-diabetic patients without periodontitis; HP: non-diabetic patients with periodontitis; DH: T2DM patients without periodontitis; DP: T2DM patients with periodontitis.
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whole transcriptome sequencingtype 2 diabetespreliminary findings indicatedifferentially expressed genebiological mechanisms underlyingdistinctive transcriptomic changesdegs confirmed changessignaling pathways associatedsectional study evaluatedingenuity pathway analysisdiv >< pipa also predictedsectional studythree degsipa predictedfunctional pathwaysakt pathwaysdistinctive genesuniquely identifiedtrna splicingptpn2 ptpn13 protein expressionpik3r2 phagosome formationperiodontal healthitga4 il1rn gingival biopsiesfour hundreddhcr24 cholesterol biosynthesiscardiac βcalcrl 6r
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