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The effects of individual lysosomal ion stressors on spherical versus tubular lysosomal physiology.

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posted on 2017-11-08, 18:42 authored by Tehetina Woldemichael, Gus R. Rosania

(A) The effect of inhibiting the number of V-ATPase molecule per lysosome showed significant changes in lysosomal pH and Cl-, with minimal change in membrane potential in both spherical and tubular lysosomes. (B) The effect of increasing proton-specific membrane permeability per lysosome showed significant changes in lysosomal pH and Cl-, with minimal change in membrane potential in both spherical and tubular lysosomes. In both (A) and (B), only a slight difference is observed in the effect of the lysosomal ion stressors on spherical versus tubular lysosomal physiology.

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