The effects of individual lysosomal ion stressors on spherical versus tubular lysosomal physiology.

(A) The effect of inhibiting the number of V-ATPase molecule per lysosome showed significant changes in lysosomal pH and Cl^-, with minimal change in membrane potential in both spherical and tubular lysosomes. (B) The effect of increasing proton-specific membrane permeability per lysosome showed significant changes in lysosomal pH and Cl^-, with minimal change in membrane potential in both spherical and tubular lysosomes. In both (A) and (B), only a slight difference is observed in the effect of the lysosomal ion stressors on spherical versus tubular lysosomal physiology.