The effect of GIPR antagonists alone or in combination with liraglutide on lipid homeostasis in DIO mice.

Effects of GIPA-1 and GIPA-2 on liver TG (A and B), liver weight (C and D), retroperitoneal fat weight (E and F) and inguinal fat weight (G and H) following administration of vehicle, liraglutide, GIPR antagonist, and liraglutide in combination with the GIPR antagonist for 28 days in DIO mice. Group sizes are n = 10, and data are represented as mean ± SEM. Statistical analysis was calculated using one-way ANOVA with Dunnett’s post-hoc test. *: p< 0.05, **: p < 0.01, ***: p < 0.001, ****: p<0.0001 compared to vehicle.

(TIF)