The dynamical behaviour of the game.

The simulations show possible population profiles of C. albicans and S. aureus over time for varying parameter settings. For the parameter details of the simulations see Table 2. The end points of the simulations show all five fixed point cases with each case representing a possible state of the biofilm. All six simulations start with a 50/50 mix of hyphae and yeast cells in the C. albicans population and a 50/50 mix of exploiting and cooperating cells in the S. aureus population. Observations at the end of the simulations: a) All C. albicans cells adopt the hyphae strategy and all S. aureus cells adopt the exploitation strategy. b) All C. albicans cells adopt the yeast strategy and all S. aureus cells adopt the exploitation strategy. c) All C. albicans cells adopt the hyphae strategy and all S. aureus cells adopt the cooperation strategy. d) After an increase in C. albicans yeast cells at the beginning of the simulation, all C. albicans cells adopt the hyphae strategy and all S. aureus cells adopt the cooperation strategy. The simulations 2c and d both end in the same biofilm state. However, the course of the curve and the time needed to reach a fixed point are parameter-dependent. e) All C. albicans cells adopt the yeast strategy and all S. aureus cells adopt the cooperation strategy. f) For the inner fixed point we see oscillations of the population profiles with all four biofilm stages being possible.