ppat.1009352.s007.tif (411.06 kB)
The correlation of CDR3 length with BC50 among anti-RBD antibodies.
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posted on 2021-02-26, 18:43 authored by Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. TownsendThe CDR3 length (number of amino acids) and MAb gene mutation numbers are presented as mean ± standard error of the mean (< 0.5 μg/ml, n = 5 versus > 0.5 μg/ml, n = 5). The two-tailed Mann-Whitney test was performed to compare the CDR3 length and mutation numbers between two groups. * P < 0.05; ns, non-significant; BC50, 50% binding concentration.
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3 weeksantibody responseSARS-CoV -2 infectionACE 2-blocking responsePotent humoral responsesCOVID -19 patientscross-inhibiting clustersneutralising antibodiesplasmablast-derived IgGAnti-RBD MAbsplasmablast responses32 anti-spike MAbsvirus spike glycoproteinACE 2non-competing pairsplasmablast responsememory B cellsanti-non-RBD S 1plasmablast-derived MAbsanti-receptor-binding domainACE 2-blocking anti-RBD antibodies
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