ppat.1011879.s006.tiff (1.6 MB)
The cocktail strategies show limited strain transcending activity.
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posted on 2024-03-04, 19:36 authored by Rui Ma, Nichole D. Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J. Jenkins, Thayne H. Dickey, Jillian Neal, Junhui Duan, Robert D. Morrison, Apostolos G. Gittis, Justin Y. A. Doritchamou, Irfan Zaidi, Lynn E. Lambert, Patrick E. Duffy, Niraj H. ToliaThe BIA assay results against WF12 parasite strain containing 7G8 VAR2CSA using purified pooled IgG at 1mg/ml from the serum after two vaccinations. The dashed line indicates the 50% inhibition level used as a cutoff for inhibitory or non-inhibitory activity, the data shown are derived from two independent experiments and each point is the mean of two technical replicates.
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plasmodium falciparum low birth weightfold greater yieldinfected erythrocytes resultsdiv >< pcocktail vaccination strategyguided design leveragingcsa interaction correlateinfected erythrocytescocktail strategyguided designdesign expressedstable immunogenreduced sizepregnancy lossplacental malariamultiple variantsmaternal anemialength structureslength proteincsa ).based immunogens
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