pgen.1010900.s002.tiff (6.88 MB)
The PqsE-RhlR interaction interface is required for PqsE-dependent DNA binding.
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posted on 2023-12-08, 18:39 authored by Nicholas R. Keegan, Nathalie J. Colón Torres, Anne M. Stringer, Lia I. Prager, Matthew W. Brockley, Charity L. McManaman, Joseph T. Wade, Jon E. PaczkowskiComparison of ChIP enrichment between the (A) WT PA14 and pqsE-D73A strains and (B) ΔpqsE and pqsE-NI strains. Comparison of gene expression between the (C) WT PA14 and pqsE-D73A strains and (D) ΔpqsE and pqsE-NI strains. Cyan and pink dots correspond to genes with a RhlR binding site <500 bp upstream of the corresponding operon, as determined by ChIP-seq, that are also differentially expressed +/- rhlR (q < 0.01) as determined by RNA-seq in an earlier study [29].
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small molecule autoinducersdiv >< ptype transcription factorsensing receptor activationdependent transcription activationpseudomonas aeruginosa different sites acrossvirulence factor productionquorum sensing behaviorspqse binds rhlrimpacts rhlr bindingmany dna sitestranscription factorp aeruginosa quorum sensingrhlr acrossgroup behaviorsdna sitesrhlr specificityrhlr quorumrhlr functionrhlr bindingmaximal rhlrtarget genessynchronous expressionseq analysesrecently showedpromoter selectivitypromoter dnaperform chipoverlapping dependenciesmaximal bindingmain driverslarge majoritygenes knowngenes involvedcell communicationbiofilm formationbacterial cell
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