Testicular CIS

Copyright information:

Taken from "Testis and Antler Dysgenesis in Sitka Black-Tailed Deer on Kodiak Island, Alaska: Sequela of Environmental Endocrine Disruption?"

Environmental Health Perspectives 2005;114(S-1):51-59.

Published online 21 Oct 2005

PMCID:PMC1874179.

This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI

() CIS-like cells (arrows) in the basal aspect of a seminiferous tubule from the testis of NCO deer 03-12. Compare the size and abnormal contours of the nuclei in these cells with those of spermatogonia in the lower tubule. Methylene blue and Safranin-O staining. () An intratubular tumorous nodule (designated by arrows) containing CIS-like cells in BCO deer 03-14. Note the foaminess and hypertrophy of Leydig cells and compare with those in . Methylene blue and Safranin-O staining. () Transmission electron micrograph of an atypical germ cell from the testis of BCO deer 03-7. Note abnormal nuclear contours, chromatin clumps, and altered nucleolonema in large nucleolus, swollen mitochondria, and unusual membranous profiles. () Transmission electron micrograph of a cluster of CIS-like cells from the testis of BCO deer 03-6. Note meandering, marginated nucleoli typical of seminomatous lesions and swollen mitochondria in each of these cells. Scale bars: and = 25 μm; and = 2 μm.