pone.0245917.s002.tif (80.05 kB)
T cell numbers of huCD3εHOM normalize in aged mice.
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posted on 2021-02-17, 18:34 authored by Joel Crespo, Yi Ting Koh, Ningjie Hu, Paul A. Moore, Ezio Bonvini, Andrew L. Glasebrook, Andrea P. Martin, Robert J. Benschop(A-B) Absolute overall, naïve and memory CD4+ (A) and CD8+ (B) T cell numbers from splenocytes of WT, huCD3εHET and huCD3εHOM mice at 6, 9, 12 and 17 months of age. n = 3–14, *p<0.05.
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CD 3 antibodiesdrug candidatesT cell-dependent antigenstype miceCD 3.knock-in modelCD 3 therapy Pre-clinical murine modelsT cellantibody titersgraft-vs-host disease modelCD 3thymocyte developmentCD 3 therapy worksresults showeffector T cell responseshumanized CD 3 murine modelhuCD 3ε HET micehuCD 3ε HET T cellshumanized-CD 3ε-exon
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