ppat.1011805.g004.tif (611.53 kB)
T cell activation measured by IFN-γ+ ELISpots from splenocytes.
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posted on 2024-01-10, 18:34 authored by Juan García-Bernalt Diego, Gagandeep Singh, Sonia Jangra, Kim Handrejk, Manon Laporte, Lauren A. Chang, Sara S. El Zahed, Lars Pache, Max W. Chang, Prajakta Warang, Sadaf Aslam, Ignacio Mena, Brett T. Webb, Christopher Benner, Adolfo García-Sastre, Michael SchotsaertN-peptide: 15-mer overlapping peptides based on the Nucleoprotein (N) sequence of SARS-CoV-2. S-peptide: 15-mer overlapping peptides based on the Spike (S) sequence of SARS-CoV-2. (A) IFN-γ-releasing splenocytes per million after stimulation with S or irrelevant Hemaglutinin (HA). Statistical analysis: Mann-Whitney U test. (B) Log10 of the fold induction calculated based on number of IFN-γ-releasing splenocytes when stimulated with S or N taking HA as reference.
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hybrid immunity resultedbroadly reactive bvaccination reduced morbidityallowed breakthrough infectionsbreakthrough infectionsreactive seravaccination statusvaccination primedvaccinated hamsterstranscriptomics postneutralizing antibodiesinterstitial macrophageshigh titersdisease coursechallenged hamsterscell responsesancestral virusancestral spike
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