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T-cell, B-cell, macrophage, and granulocyte expression in the synovium of mice with collagen-induced arthritis, after 7 days of IFN-β therapy, detected by immunohistochemistry

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posted on 31.12.2011, 04:37 by Judith van Holten, Kris Reedquist, Pascale Sattonet-Roche, Tom JM Smeets, Christine Plater-Zyberk, Margriet J Vervoordeldonk, Paul P Tak

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Taken from "Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis"

Arthritis Research & Therapy 2004;6(3):R239-R249.

Published online 23 Mar 2004


Copyright © 2004 van Holten et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Sections were scored for CD3 and CD22 as described in Materials and methods. Macrophages and granulocytes were evaluated by morphology. CD3 expression. CD22 expression. Macrophage expression. Granulocyte expression. No significant differences between treated animals and controls were observed for CD3 and CD22 expression (= 0.4 for both). Statistically significant differences were observed for macrophage and granulocyte expression between IFN-β-treated mice and saline-treated mice (= 0.04 and 0.009, respectively). *Statistically significant difference.