pone.0245526.g001.tif (1.11 MB)
TCS in 30 cases of INSS Stage 4 neuroblastoma.
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posted on 2021-01-19, 18:41 authored by Shunsuke Kimura, Masahiro Sekiguchi, Kentaro Watanabe, Mitsuteru Hiwatarai, Masafumi Seki, Kenichi Yoshida, Tomoya Isobe, Yusuke Shiozawa, Hiromichi Suzuki, Noriko Hoshino, Yasuhide Hayashi, Akira Oka, Satoru Miyano, Seishi Ogawa, Junko Takita(A) Recurrently detected gene alterations (> 10%) by TCS for 381 pediatric cancer-related genes. Since only tumor samples were available, candidate variants were filtered according to our previous study to estimate somatic mutations. (B) Mutational landscape in 30 cases of neuroblastoma, along with copy number alterations based on TCS data. TCS, targeted capture sequencing. Broad and focal deletions and amplifications in the coding regions were also annotated in “Gene alteration”.
