pntd.0011001.g006.tif (1007.57 kB)
TBK1 and IRF3 interventions on EV-A71-induced proinflammatory cytokines expression in mice.
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posted on 2023-01-10, 18:23 authored by Wangquan Ji, Tiantian Sun, Dong Li, Shuaiyin Chen, Haiyan Yang, Yuefei Jin, Guangcai DuanThe concentrations of IL-6, TNF-α, IL-1β, MCP-1and IL-10 in the brains (A-E) and lungs (F-J) of mice at 5 dpi were determined using ELISA. The data are shown as means ± SD. n = 3 or 4 per group; EV-A71 vs Control; EV-A71-infected mice with TBK1 and IRF3 interventions vs EV-A71-infected mice. * P < 0.05; **P < 0.01; ns, not significant. All the experiments were repeated at least three times.
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xlink "> collectivelyunderlying molecular mechanismtumor necrosis factorsevere pathological alterationsregulatory factor 3potential therapeutic targetsmuscle fiber breaksmonocyte chemotactic proteinimportant causative agentfused alveolar wallsdiffuse congestion occurredtbk1 inhibitor administrationinnate immune responseinfected mice treatedinfected mice administratedil )- 6applied tbk1 inhibitorbinding kinase 1α ), ilinduced inflammatory responseirf3 agonist alleviatedirf3 agonist1 ),induced typeinduced illnesswell describedvivo socioeconomic burdenneuronal degenerationmouth diseasefully understoodfirst timefindings suggestenormous healthcareclinical manifestationsantiviral activities
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