pntd.0010159.g004.tif (842.71 kB)
Survival curves of Galleria mellonella larvae infected with Madurella mycetomatis and treated with selected compounds.
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posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandeThe blue dashed line in all panels represents the non-infected controls while the black line represents the infected control. Panel A displays the survival of larvae treated with azoles Miconazole, Ravuconazole, Oteseconazole, Eberconazole and Luliconazole. Panel B, the survival of larvae treated with benzimidazole carbamates Fenbendazole, Carbendazim and MMV1782387. Panel C and D displays the survival of larvae treated with the other MMV compounds MMV1634491, MMV019724, Alexidine, Amorolfine, Tafenoquine and Olorofim. Significant survival was displayed as * (0.01
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pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
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