pone.0262657.g003.tif (364.78 kB)
Surrogate SARS-COV-2 neutralization assays.
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posted on 2022-01-18, 18:30 authored by Adam V. Wisnewski, Jian Liu, Carolina Lucas, Jon Klein, Akiko Iwasaki, Linda Cantley, Louis Fazen, Julian Campillo Luna, Martin Slade, Carrie A. RedlichCompetitive RBD-ACE2r ELISAs with paired pre/post COVID-19 vaccine serum at different concentrations (X-axis) from 6 different subjects without prior COVID-19 before vaccine (black dashed lines) or day 7–10 post full vaccination (red solid lines). ELISA OD values reflecting RBD-ACE2r binding are shown on Y-axis. Subject 1 (square), subject 2 (inverted triangle), subject 3 (circle), subject 4 (triangle), subject 5 (octagon), subject 6 (diamond).
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live viral cultureshighlights marked declinesfindings raise concernaccomplished using pairs42 vaccinated individualssoluble biotinylated ace2race2r inhibitory activitysurrogate neutralizing activityreceptor binding domainpost vaccine serumhelp assess responsesbooster vaccine dosesxlink "> testslongitudinal analyses precompetitive elisa basedxlink ">vaccine responsescompetitive elisaace2r interactionsvaccine receivedhost receptorwithout ),surrogate sarssub ><significant differencespublished studiesprior historypotential needmay wanegold standardfell substantiallyexcellent correlationevaluate nenable evaluationcentral roleadditional n>32 samples2 immunity0001 ).
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