The supplemental material depicts additional information of manuscript MS# JAPPL-00241-2025 about Temporal evolution of protocol at 12th week, representative esophageal pressure tracings of CTRL and RLR animals, representative figures of blood flow in the pulmonary artery obtained by Doppler at BASELINE, 6 and 12 weeks after radiation and representative short-axis images of left (LV) and right ventricle (RV) at BASELINE, 6 and 12 weeks after radiation, quantification of smooth muscle actin positive cells (α-SMA) in left and right lung of CTRL and RLR animals and representative smooth muscle actin positive cells (α-SMA) of CTRL and RLR after 12 weeks of irradiation.