Sugar-sensing TrmB homologs.

A) Phylogenetic distribution of TrmB proteins that also contain a carbohydrate-binding domain. B) Multiple sequence alignment of the sugar-binding domain of Har. hispanica TrmB homologs. Red, underlined residues are essential for sugar binding in Tcc. litoralis, conserved residues are in bold underline [73, 74]. Asterisks below the alignment denote identical residues and dots represent similar residues. Organism abbreviations and locus tags are as follows: TLI_TRMB, Tcc. litoralis OCC_03542; PFU_TRMBL1, Pyr. furiosus PF0124; TKO_TGR, Tcc. kodakaraensis TK1769; HBT_TRMB, Hbt. salinarum VNG_1451C. Har. hispanica TrmB homologs are named according to their identity to characterized proteins.