Subclass/isotype functional coordination varies by regimen/vaccine strategy.

The heatmaps show Spearman correlations across antibody functional measurements and subclass/isotype levels for: A: 077 trials, with each heatmap depicting a different trial arm, left to right: T1, T2, T3; B: the DNA and rAd5 trial 204; C: the DNA/AIDSVAX B/E trial 105, trial arms T1 to T4; D: Trial 078 NYVAC/rAd5 (T1 and T2 arms); E: Trial 205 using DNA/MVA (T3 and T4). Red depicts high positive correlation coefficients, whereas blue displays a negative correlation, P values were Bonferroni corrected for multiple comparisons, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.