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Structure of the bat influenza A polymerase (PDB: 4WSB).

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posted on 2021-06-01, 17:41 authored by Daniel H. Goldhill, Ada Yan, Rebecca Frise, Jie Zhou, Jennifer Shelley, Ana Gallego Cortés, Shahjahan Miah, Omolola Akinbami, Monica Galiano, Maria Zambon, Angie Lackenby, Wendy S. Barclay

This shows the location of the active site in white and K229 in red. The homologous position to 321 is shown in dark green and 653 in blue.

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    PLOS Pathogens

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    polymerase activitygain wild-type PB 1 segmentPA P 653Lwhilst favipiravir-resistant virusK 229Rfitness advantageP 653LPB 1 resistance mutation K 229RpH 1N influenza

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