pntd.0011803.s006.tif (200.01 kB)
Stratification of single blood cells in cases versus controls.
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posted on 2023-12-06, 18:35 authored by Peter Nambala, Julius Mulindwa, Harry Noyes, Vincent Pius Alibu, Barbara Nerima, Joyce Namulondo, Oscar Nyangiri, Enock Matovu, Annette MacLeod, Janelisa Musaya(A) First and second principal components of the proportions of different cell types by phenotype. The cases and controls are separated along PC1. (B) Plots showing normal distribution of the transformed bulk RNA-Seq data into blood single cell RNA-seq data.
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significant differentially expressedfuture research whetherhuman transcriptome profilesgene expression profiles4 – 2lipid metabolism genes7 controls excluded28 healthy controlsr studio usingidentified biological pathwayshat case samplesstage 2 rgene enrichment analysisearly stage 1malawi stage 2stage 1transcriptomic profilescontrol samplesdownstream analysisdifferential analysis4519 genes1824 genes23 rrhodesiense p adjustedneutrophil activationmalawi varieslate stagesinnatedb algorithmsidentified transcriptsfunctional annotationdeseq2 packagedata addcurrent understandingclinical presentationcausative agentb age range
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