Stereoselective Synthesis of Ganodone

This is a stereoselective synthesis of both enantiomers of the natural product Ganodone which goes via the introduction of diastereomers (using either R or S CBS) during the synthesis and a subsequent chiral resolution via FCC. This will of course reduce the yield of the desired product, but the syntheis is relatively short.

The reference for the natural product Ganodone can be found in the ACS Journal of Natural Products at the following DOI:10.1021/np200361y).

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