ppat.1012050.g001.tif (281.17 kB)
Stepwise evolution of LldD2.
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posted on 2024-02-29, 18:55 authored by Sydney Stanley, Xin Wang, Qingyun Liu, Young Yon Kwon, Abigail M. Frey, Nathan D. Hicks, Andrew J. Vickers, Sheng Hui, Sarah M. FortunePhylogenetic tree of 296 M. tuberculosis and M. africanum clinical isolates representing the global diversity of the Mycobacterium tuberculosis complex (MTBC). The tree scale denotes number of mutations per site. Ancestrally derived lineage and sub-lineage defining lldD2 mutations are indicated by a bar. Triangles denote de novo or homoplastic mutations. Total number of mutations per strain is tallied to the right of the phylogenetic tree.
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providing experimental evidencediv >< pcentral carbon metabolism1 virulence systemmycobacterium tuberculosis discernible growth defectdependent antibiotic susceptibilitymutations functionally increasehuman host environmentglobal clinical isolateslactate dehydrogenase revealsassessing mtb genes13 clinical isolatesvivo mtb growthlactate dehydrogenaseintracellular environmenthost pressuregenes involveddependent lvariation acrosstranscriptionally sensitivesugar phosphatesstrongest targetsstepwise natureselective advantagesalient featurerobust incorporationprovides contextpressures facingpoorly characterizedpleiotropic effectsmycobacterial cellmultifunctional rolemtb genomelldd2 lactate accumulationfunctional reporterdetoxification benefitdeleterious buildupdefining mutationsdata illustratebacterial determinantsbacterial adaptionancestral lineage
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