Stability of cLD and LD revealed by closed-form variance calculation and bootstrapped distributions.

a) The gene pairs were split into four different bins based on the cMAF values, i.e., <0.05, 0.05–0.10, 0.10–0.20, and 0.20–0.40 (y-axis). The x-axis is the ratio between the variances of cLD and LD, i.e., Var(cLD)/Var(LD). b) Probability density distribution of cLD and LD from bootstrapped samples. Results from the European population are shown. See Figs A and B in S1 Text for other populations.