pcbi.1009476.g007.tif (202.84 kB)
Spiral wave breakup in a 2D model for optogenetically-modified neonatal mouse ventricular tissue.
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posted on 2021-10-08, 17:32 authored by Rupamanjari Majumder, Sayedeh Hussaini, Vladimir S. Zykov, Stefan Luther, Eberhard BodenschatzA Intact spiral in the presence of uniform, global, constant illumination (Ee = 0.025 mW/mm2). B Break up in the presence of periodic optical stimulation (0.025 mW/mm2, 4 Hz, PW = 200 ms).
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threshold illumination régimespatially extended mediumlesser studied sublethal rhythm disordershuman atrial tissuecardiac arrhythmia researchnonlinear wave propagationdiv >< pcardiac arrhythmias requireswave break initiationcardiac tissuecardiac rhythmwave breakcalled arrhythmiaswave profilewave breakswaveback interactionsudden deathsilico restitution characteristicspotentially lifenew mechanismmechanism involvesmain causesindustrialized worldimportant questionsimportant contributionidentifies scenariosheterogeneous recoverygentle slopesexcitable windowsenergy perturbationsdetailed understandingconduction blockscommonly referredbreaks evolve
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