Fig 4.TIF (762.28 kB)
Specific verses non-specific cleavage rate of apt-3683 in the presence & absence of mycolactone.
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posted on 2016-10-24, 17:30 authored by Samuel A. Sakyi, Samuel Yaw Aboagye, Isaac Darko Otchere, Albert M. Liao, Thomas G. Caltagirone, Dorothy Yeboah-ManuSpecific verses non-specific cleavage rate of apt-3683 in the presence & absence of mycolactone.
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case detectionWorld Health OrganizationOD 450BU casesbacteria whilstBuruli Ulcer Background Buruli ulcerSELEX processROC analysisRNA aptamersenzyme-linked oligonucleotide assayPCR methodBUDMethods Aptamerssubcutaneous skin disease3- minute time coursetitration calorimetrydetection moleculesDiagnostic Tooldisfiguring naturemicro-molar rangeApt -3683CCmycolactoneBU patients2404 PCRnon-specific autocatalysisanti-mycobacterial drugsMycobacterium smegmatisITCSelected aptamersRNA Aptamercleavage differenceROC curve analysisnovel classELONA assayresearch agendasdissociation constantsTB treatment
