Somatic stimulation with a flipped Na_V distribution: Backward AIS.

When the AIS Na_V distribution is flipped proximal-to-distal, setting x = 1 concentrates Na_V1.6 at the proximal AIS and Na_V1.2 at the distal AIS—the opposite of what is observed in many pyramidal cells [15–17]. (A) AIS with proper longitudinal placement of Na_Vs. (B) AIS with a longitudinally flipped Na_V distribution. In both plots, x = 0.5 and κ = 0.5. (C) Somatic stimulation with AIS Na_Vs flipped as in (B): This result is close to a mirror image of Fig 2. The lines have been drawn to guide the eye.