pone.0262657.g002.tif (207.62 kB)
Soluble human ACE2r binding to plate bound SARS-CoV-2 antigen receptor binding domain (RBD).
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posted on 2022-01-18, 18:30 authored by Adam V. Wisnewski, Jian Liu, Carolina Lucas, Jon Klein, Akiko Iwasaki, Linda Cantley, Louis Fazen, Julian Campillo Luna, Martin Slade, Carrie A. RedlichBiotin labeled human ACE2r (varying concentration in ng/mL on X-axis) was diluted in buffer or 1/20 serum (see key) and binding to RBD was quantified by ELISA (OD Y-axis) using HRP-labeled streptavidin.
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live viral cultureshighlights marked declinesfindings raise concernaccomplished using pairs42 vaccinated individualssoluble biotinylated ace2race2r inhibitory activitysurrogate neutralizing activityreceptor binding domainpost vaccine serumhelp assess responsesbooster vaccine dosesxlink "> testslongitudinal analyses precompetitive elisa basedxlink ">vaccine responsescompetitive elisaace2r interactionsvaccine receivedhost receptorwithout ),surrogate sarssub ><significant differencespublished studiesprior historypotential needmay wanegold standardfell substantiallyexcellent correlationevaluate nenable evaluationcentral roleadditional n>32 samples2 immunity0001 ).
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