pcbi.1009331.g001.tif (716.69 kB)

Simplified representation of the coagulation cascade.

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posted on 2021-09-07, 17:47 authored by Noelia Grande Gutiérrez, Mark Alber, Andrew M. Kahn, Jane C. Burns, Mathew Mathew, Brian W. McCrindle, Alison L. Marsden

Intrinsic and extrinsic pathways and proposed pathway for aneurysm induced thrombosis (increased platelet activation + PolyP). TF = Tissue Factor, AP = Activated platelet, RP = Resting platelet, PolyP = Polyphosphate.

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yet fully understood suggesting predictive capabilities persistent aneurysms requires intrinsic coagulation pathway healthy coronary case diffusion equations solved coagulation pathway even clinical decisions regarding case &# 8212 thrombotic risk assessment computational simulations show computational fluid dynamics biochemical &# 8212 thrombosis prevention tailored coronary artery thrombosis activated platelet concentrations local agonist concentration track platelet activation major risk associated local concentration platelet aggregation high risk computational modeling biochemical activation confirmed thrombosis concentration levels underlying mechanisms term management reported location rate exposure potential initiation leading factors kawasaki disease including three flow stagnation findings suggest extrinsic factor coagulant environment anticoagulation therapy adenosine diphosphate activated platelets

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