pone.0290493.s002.tif (167.23 kB)
Significantly differentially expressed genes comparing low cys vs normal cys.
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posted on 2024-01-05, 18:37 authored by Judith C. W. de Jong, Kristel S. van Rooijen, Edwin C. A. Stigter, M. Can Gülersönmez, Marcel R. de Zoete, Janetta Top, Matthijs J. D. Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W. C. van Mil, Noortje IjssennaggerA) Heatmap of the 16 significantly differentially expressed genes identified by RNA sequencing on small intestinal scrapings comparing low cys to normal cys (log fold change > 1.5, p-value < 0.05). RNA sequencing on colonic scrapings did not show any significant different genes.
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stem cell markersintestinal mucus layergut microbiome compositionbile acid conjugationapparent systemic effects88 million peoplelow cystine feedinglow cystine concentrationintermolecular cystine bridgeshigh fat dietlow cystine dietincreased epithelial proliferationgoblet cell numberslow dietary cystinediv >< ptherefore inherently lowproliferative capacity specificallyessential amino acidmice proliferative capacitycystine restrictionvegetarian dietproliferation markerki67 goblet cellsdietary intakewnt signalingwhole grainsvegetarian dietssufficient uptakeprotein synthesisplasma methioninelargely dependentfound earlierbarrier function2 weeks
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