pone.0295839.g001.tif (478.19 kB)
Serum concentration of BMP8B.
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posted on 2023-12-21, 18:53 authored by Nadella Mounika, Angeera Yadav, Parul Kamboj, Sanjay K. Banerjee, Utpal Jyoti Deka, Savneet Kaur, Ramu AdelaBMP8B concentration (pg/ml) was measured in serum samples of control (n = 56), NAFL (n = 72), and NASH (n = 77) patients by using an ELISA kit. Kruskal-Wallis One-way ANOVA followed by Dunn’s multiple comparison test was applied to check the statistical significance between the groups. ***p = 0.0001, #p < 0.0001. Abbreviations: BMP8B: Bone morphogenetic protein-8B; NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis; ELISA: enzyme-linked immunosorbent assay.
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invasive predictive biomarkersinvasive predictive biomarkerinos -/- fed045 ), aprisignificant positive correlationcirculatory bmp8b levelsbmp8b shows potentialinos -/-) micecdhf ), inosshown high sensitivityincreased bmp8b levelsbmp8b mrna expressionnash ), fibrosiswt mice fednash )study findings confirmedidentify nafld progressionbmp8b expression009 ),significant associationincreased parallelfibrosis scorecdhf dietbmp8b increasesxlink ">wild typesignificantly highersectional studypresent crossnonalcoholic steatohepatitisnafld urgeslarge numberincreasing prevalenceimmunohistochemistry analysishepatocellular carcinomahepatic tissueshepatic tissuehealthy controlsfuture studieselisa kitaspartate aminotransferasealcoholic steatohepatitis91 %)73 %)4 score
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