Sensitivity of Fgf on-time.

(a) Trajectory of Nanog/Gata6 expression over time for different Fgf on-time. Each dot represents one cell. The color of the cell represents the stage of the cell. Dashed circles represent the range of Nanog/Gata6 expression levels for different stages: dark blue for 16C-32C, little blue for 32C-64C and orange for 64C-128C. (b) Bias of Nanog or Gata6 gene expression level from the initial state (16C) in simulation with different Fgf on-time. Red curve shows the cells whose Nanog expression is higher than cells in initial state; Blue curve shows the cells whose Gata6 expression is higher than cells in initial state. The vertical line shows the error bar with one standard deviation.