pone.0297625.g001.tif (810.11 kB)
Schematic representation of the phage display panning procedure.
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posted on 2024-03-05, 18:27 authored by Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung NguyenThe positive selection (the 1st, 2nd, 3rd, and 5th rounds) and negative selection (the 4th round) were performed against NT1 and OHC pooled serum IgG, respectively.
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neurons producing orexinnarcolepsy type 1mediated immunity ratherdifferential binding capacityalso named hypocretinserum immunoglobin gnt1 patient cohortunbiased random peptidespecific antigens targetedohc control groupmer peptides derivednt1 serum iggtargeted methodologiesspecific autoantibodiesvarious peptidesstatistically significantselective lossselected usingrtn4 proteinsprevious studiesorexinergic neuronohcs ).lateral hypothalamushypersomnolence complaintshigh reactivityautoimmune responseautoimmune disease
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