pgen.1011084.g007.tif (785.18 kB)
Schematic of mDia heterodimers in hematopoiesis.
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posted on 2023-12-29, 21:01 authored by Zhaofeng Li, Meng Su, Xinshu Xie, Pan Wang, Honghao Bi, Ermin Li, Kehan Ren, Lili Dong, Zhiyi Lv, Xuezhen Ma, Yijie Liu, Baobing Zhao, Yuanliang Peng, Jing Liu, Lu Liu, Jing Yang, Peng Ji, Yang MeiA. A putative bracelets-like structure composited by mDia1-mDia2 interaction. (B) A newly proposed active zipper-like confirmation assembled by mDia1-mDia2 heterodimer in this study.
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serum response factorlinear actin nucleationinvolved transcriptional signalingfilamentous actin networkmdia2 regulates enucleationmdia2 dad domainsmdia formins interplaymdia2 form heteromdia1 deficiency leadsmdia heterosignificant mortalitysevere anemiaserial platingrodent functionsregulate hematopoiesisprogenitor cellspotential rolespolymerization activitiesnewborn micemyeloid ablationmouse modelmdia1 gbdinduces myelodysplasiahspcs activityhspcs ).hspc regenerationhematopoietic stemdouble knockoutdeclined hspcsdata demonstrate
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