Schematic diagram showing the layout of the microfluidic neuronal devices.

The neuronal device is divided into a cell body compartment (blue) and axonal compartment (yellow) These two compartments are connected by microgrooves, which allow the growth of axons from the cell body side to the axonal side. Shown are sensory DRG neurons at the time of seeding in the cell body compartment (left panel) and axon growth after 3 days in the axonal compartment (right panel). Scale bar = 100 μm.

(TIF)