pone.0260500.s008.tiff (58.97 MB)
Scatter plots of single-sample gene set enrichment scores in pretreatment tumor tissues.
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posted on 2021-11-29, 18:51 authored by Tomoiki Aiba, Chieko Hattori, Jun Sugisaka, Hisashi Shimizu, Hirotaka Ono, Yutaka Domeki, Ryohei Saito, Sachiko Kawana, Yosuke Kawashima, Keisuke Terayama, Yukihiro Toi, Atsushi Nakamura, Shinsuke Yamanda, Yuichiro Kimura, Yutaka Suzuki, Atsushi Niida, Shunichi SugawaraFor each gene set in the top 20 GSEA gene sets that were enriched in pretreatment tumor tissues of responders (A) and nonresponders (B) with LUAD, the enrichment scores and dispersions were calculated using singscore. Red circles denote responders (n = 4); cyan circles, nonresponders (n = 11). The enrichment scores were analyzed using the Wilcoxon rank sum test.
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promote antitumor immunityclinically annotated cohortachieved clinical successmolecular targeted agentgene expression signaturesnivolumab may functionl1 expressionimmunomodulating agenttumor cellstranscriptome sequencingsamples obtainedquite differentpredictive biomarkerperformed wholensclc patientslung adenocarcinomainherently immunogenicfindings suggestedcandidate biomarkers
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