pcbi.1010030.g006.tif (186.96 kB)

Sample activation pattern.

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posted on 2022-04-01, 17:35 authored by Damiano Fassina, Caroline M. Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E. Harding, Steven A. Niederer

Upper row: propagation in a healthy slab. Lower row: propagation in a sample simulation of the fixed setup, showing the delay in REAT activation.

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sup >+key step toward global sensitivity analysis epicardial patches constructed consistent across species cardiac myocyte electrophysiology associated arrhythmic risk restoring physiological activation recovered physiological activation match healthy activation increased arrhythmia risk epicardial patch spanning eht patches observed restore physiological propagation stimulus propagation paths transmural cross section successful patch engraftment small animal studies patch geometrical dimensions mi activation properties gsa sensitivity indices eht design variables div >< p cms immature phenotype cardiac electrophysiology model tuning eht conductivity 1 – 1 may restore pre understanding electrical interaction increasing eht conductivity eht patch conductivity host myocardium represents stimulus propagation restore pre electrical activation patch design mi activation eht conductivity tested increasing may lead increased na engraftment site eht na mi ).host myocardium tissue dimensions vitro term therapy small animals simulations predict silico scale differences results revealed qualitatively reproduce model suggests model revealed model featured mainly governed infarct region important parameters derived cardiomyocytes cp ).conductive polymer comparing simulations channel density bath region alternative strategy aid non

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