pone.0289439.g001.tif (463.54 kB)
SPIRIT study schedule for participant enrollment and assessments.
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posted on 2024-03-13, 17:32 authored by Haliton Alves de Oliveira Junior, Precil Diego Miranda de Menezes Neves, Gustavo Bernardes de Figueiredo Oliveira, Frederico Rafael Moreira, Maria Carolina Tostes Pintão, Viviane Zorzanelli Rocha, Cristiane de Souza Rocha, Viviane Nakano Katz, Elisa Napolitano Ferreira, Diana Rojas-Málaga, Celso Ferraz Viana, Fabiula Fagundes da Silva, Juliete Jorge Vidotti, Natalia Mariana Felicio, Leticia de Araújo Vitor, Karina Gimenez Cesar, Camila Araújo da Silva, Lucas Bassolli de Oliveira Alves, Álvaro AvezumSPIRIT study schedule for participant enrollment and assessments.
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whole exome sequencingsingle nucleotide polymorphismperipheral artery thromboticmultiple logistic regressioneffect alleles observedacute myocardial infarctionatherosclerotic cardiovascular diseasegenetic profile derivedpopulation attributable risksdiv >< plikely pathogenic variantspolygenic risk scoresnp ), number8 genes (<nationwide genetic casebrazil polygenic natureci ),cardiovascular genesgenetic polymorphismsgenetic backgroundgenetic analysesrisk factorpopulation levellarge populationpcsk9 lipa ldlrap1 ldlr apoe apob abcg8 abcg5 total numbersnps includedmissing snpsleading causeischemic eventsindividual screeninginclusion criteriongov (<death worldwidedata collectedcore labconfidence intervalsascvd risk>) associated734 patients1 case
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