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SB T2/Onc3 TG.12740 allele donor position mapping and exclusion for SB Driver Analysis.

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posted on 2021-08-16, 17:38 authored by Aziz Aiderus, Justin Y. Newberg, Liliana Guzman-Rojas, Ana M. Contreras-Sandoval, Amanda L. Meshey, Devin J. Jones, Felipe Amaya-Manzanares, Roberto Rangel, Jerrold M. Ward, Song-Choon Lee, Kenneth Hon-Kim Ban, Keith Rogers, Susan M. Rogers, Luxmanan Selvanesan, Leslie A. McNoe, Neal G. Copeland, Nancy A. Jenkins, Kenneth Y. Tsai, Michael A. Black, Karen M. Mann, Michael B. Mann

Cumulative SB insertion sites at TA-dinucleotides from (A) 454_Splink and (B) Ion_SBCapSeq datasets showing the likely TG.12740 donor site at 87,000,000 bp and the exclusion region (yellow box) between 79,000,000 and 95,000,000 bp applied when SB Driver Analysis was run on chromosome 9. The 81 genes between Filip1 at chr9:79663368–79825689 and Tfdp2 at chr9:96096693–96224065 were excluded from SB Driver Analysis. The complete list of 81 genes excluded from SB Driver Analysis from tumors harboring the SB T2/Onc3 TG.12740 donor allele: 1190002N15Rik, 1700034K08Rik, 1700057G04Rik, 1700065D16Rik, 4930524O08Rik, 4930554C24Rik, 4933400C23Rik, 9330159M07Rik, 9430037G07Rik, A330041J22Rik, Adamts7, AF529169, Ankrd34c, Atr, B430319G15Rik, Bckdhb, Bcl2a1a, Bcl2a1b, Bcl2a1d, Cep162, Chst2, Ctsh, Cyb5r4, D430036J16Rik, Dopey1, Elovl4, Fam46a, Gk5, Hmgn3, Htr1b, Ibtk, Impg1, Irak1bp1, Lca5, Me1, Mei4, Mir184, Mir6386, Mir7656, Morf4l1, Mrap2, Mthfs, Mthfsl, Myo6, Nt5e, Paqr9, Pcolce2, Pgm3, Phip, Plod2, Pls1, Plscr1, Plscr2, Plscr4, Plscr5, Prss35, Rasgrf1, Ripply2, Rwdd2a, Senp6, Sh3bgrl2, Slc9a9, Snap91, Snhg5, Snx14, Syncrip, Tbc1d2b, Tbx18, Tmed3, Tpbg, Trim43a, Trim43b, Trim43c, Trpc1, Ttk, U2surp, Ube2cbp, Xrn1, Zfp949, Zic1, Zic4.

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