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SARS-CoV-2 VOC in animal models.

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posted on 2022-01-13, 18:23 authored by César Muñoz-Fontela, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie de Wit, Michael S. Diamond, William E. Dowling, Simon G. P. Funnell, Adolfo García-Sastre, Nora M. Gerhards, Rineke de Jong, Vincent J. Munster, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Ximena Riveros-Balta, Chad J. Roy, Francisco J. Salguero, Michael Schotsaert, Lauren M. Schwartz, Robert A. Seder, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo, Dan H. Barouch

The schematic summarizes findings related with virulence, transmission, and cross-protection gathered in the indicated animal models so far. Figure created with Biorender (Biorender.com). huACE2, human angiotensin I-converting enzyme 2; K18, cytokeratin-18; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; VOC, variant of concern.

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    PLOS Pathogens

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    world health organizationinvestigate voc pathogenesisfacing new challengesevaluate voc virulenceanimal model researchcoronavirus disease 201919 demographic variablesparticular animal modelsanimal modelspreclinical modelsxlink ">vocs ).vaccine inequityvaccine correlatespostexposure therapieskey roleimmune escapeglobal response2 variants

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