pgen.1010777.s006.tif (5.34 MB)
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posted on 2023-11-27, 19:20 authored by Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. HendersonIPA analysis on the “cardiac development” filtered CS16/CS19 combined dataset showing all statistically significant A) canonical pathways and B) upstream transcriptional regulators. A) canonical pathways and B) upstream transcriptional regulators identified using Ingenuity Pathway Analysis (IPA) to scrutinise the CS16/19 combined dataset. Filtering for “cardiac” and “development”. This complements the data provided in Fig 5.
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xlink "> abnormalitiesusing spatial transcriptomicsseveral days apartnovel &# 8221highlight &# 8220common congenital defectsgenomic data analysesexpression data confirmarterial valves formdeveloping heart valvesdeveloping arterial valvesrelated genes maydifferentially expressed genesmouse atrioventricular valvesarterial valve defectssignalling pathways importantarterial valve developmentarterial valvesgenes importantdeveloping embryodata suggestsvalve developmentmouse knockoutsmouse genomecardiac developmentvalve transcriptomestiny structuresstill muchsmall sizesignificant causerelative inaccessibilitylater lifeincluding fourhuman gestationhuman embryosgreat majoritygenetic levelcausative variantsaccurately dissecting
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