ppat.1009991.s005.tif (2.75 MB)
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posted on 2021-10-05, 17:32 authored by Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Jean-Marie Launay, Gerold Schmitt-Ulms, Benoit Schneider(A) Representative western blot of PDK4 protein expression level, (B) PDH activity, and (C) Nissl staining of viable neurons in the hippocampus of C57Bl6/J mice infected or not with Fk6 prions sacrificed at 130 days post-infection (n = 4). Scale bar = 100 μm. GAPDH was used for normalization in western-blot experiments. Data are the mean ± SEM. **** denotes p < 0.0001.
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remain poorly elucidatedpotential therapeutic targetoxidative stress conditionsidentify therapeutic targetsfatty acids βbovine spongiform encephalopathiesmad cow diseasesc c study posits pdk4pyruvate dehydrogenase complexpathogenic prions prpglucose oxidative degradationdiv >< pprion protein controlcellular prion proteinprotein kinasejakob diseaseprion diseasessubsequent onsetplasma membranepdk4 extendspdk4 activitypdk4 ).neurodegeneration occurringmouse hippocampusmolecular pathwaysmetabolic roleinfected miceglobal approachesevent favorsenergetic metabolismdependent mannerbetter understandingbetter known
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