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posted on 2023-11-27, 19:20 authored by Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. HendersonA) GenePaint images for all of the top 30 cushion cluster genes (as shown in Fig 3A) and B) RNAscope images of ID4 and PDLIM3 at CS19. A) The whole embryo for each gene is shown on the left and a higher magnification image of the heart is shown on the right. Blue arrows in the Col 1A2 images point to the arterial valves whereas the red arrows point to the atrioventricular valves. Similar images are shown for each gene. For almost every gene (with the exception of C7), high level expression is seen in the valve tissue. B) Arrows point to regions of high-level expression in the pulmonary valve.
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xlink "> abnormalitiesusing spatial transcriptomicsseveral days apartnovel &# 8221highlight &# 8220common congenital defectsgenomic data analysesexpression data confirmarterial valves formdeveloping heart valvesdeveloping arterial valvesrelated genes maydifferentially expressed genesmouse atrioventricular valvesarterial valve defectssignalling pathways importantarterial valve developmentarterial valvesgenes importantdeveloping embryodata suggestsvalve developmentmouse knockoutsmouse genomecardiac developmentvalve transcriptomestiny structuresstill muchsmall sizesignificant causerelative inaccessibilitylater lifeincluding fourhuman gestationhuman embryosgreat majoritygenetic levelcausative variantsaccurately dissecting
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