ppat.1009991.s002.tif (3.24 MB)
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posted on 2021-10-05, 17:32 authored by Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Jean-Marie Launay, Gerold Schmitt-Ulms, Benoit SchneiderRepresentative Western blots of AldoA (A), TPI (B), Eno3 (C), PGAM1 (D), ADH (E), OGDH (F), CS (G), PDHA1 (H), and DLD (I) expression in 1C11 and PrPnull-1C11 cells. α-tubulin was used for normalization.
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remain poorly elucidatedpotential therapeutic targetoxidative stress conditionsidentify therapeutic targetsfatty acids βbovine spongiform encephalopathiesmad cow diseasesc c study posits pdk4pyruvate dehydrogenase complexpathogenic prions prpglucose oxidative degradationdiv >< pprion protein controlcellular prion proteinprotein kinasejakob diseaseprion diseasessubsequent onsetplasma membranepdk4 extendspdk4 activitypdk4 ).neurodegeneration occurringmouse hippocampusmolecular pathwaysmetabolic roleinfected miceglobal approachesevent favorsenergetic metabolismdependent mannerbetter understandingbetter known
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