ppat.1009543.s002.tif (6.56 MB)
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posted on 2021-09-24, 17:38 authored by Safia S. Aljedani, Tyler J. Liban, Karen Tran, Ganesh Phad, Suruchi Singh, Viktoriya Dubrovskaya, Pradeepa Pushparaj, Paola Martinez-Murillo, Justas Rodarte, Alex Mileant, Vidya Mangala Prasad, Rachel Kinzelman, Sijy O’Dell, John R. Mascola, Kelly K. Lee, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, Marie Pancera(A) Side and top view of D11A.F2 Fab (Heavy chain, sky blue; Light chain, cyan) bound to the V2b peptide (yellow) and crystallization artifacts peptide (purple). (B) 2Fo-Fc and Fo-Fc electron density showing clear density for the artefact peptide. (C) Side and top view of D11A.B5 Fab (Heavy chain, magenta; Light chain, light pink) bound to the V2b peptide (yellow) and crystallization artifacts peptide (purple). (D) 2Fo-Fc and Fo-Fc electron density showing clear density for the artefact peptide.
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variable region 2structural analysis revealsray crystallography identifiednative flexibly linkedguiding immunogen designfacilitate trimer redesigndifferent tier 2crystal structures revealedatomic level information1 envelope glycoproteinpotent neutralizing capacitypotent autologous neutralizationautologous neutralization elicitedpotentially elicit crossinduced antibodies derivedanalyzed monoclonal antibodiesreactive neutralizing antibodiesvaccine development aimedv2 segment adoptsdiv >< p16055 nfl trimerautologous viruseliciting cross16055 strainantibodies targetneutralizing hivstructurally relatedstain empotencies rangingnabs ).multiple anglesmolecular mechanismshuman primatesglycan shieldconserved regionscommon epitopebetter targetbased immunogens68 μg
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