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posted on 2021-06-17, 17:25 authored by Mohammad Khursheed Siddiqi, Chae Kim, Tracy Haldiman, Miroslava Kacirova, Benlian Wang, Jen Bohon, Mark R. Chance, Janna Kiselar, Jiri G. Safar

Hydroxyl radical modification rate of residues in (a) α-helical monomers of recHuPrP(129M) and rPrP(129V), and (b) sCJD MM1, MM2, and VV2 prions.

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    PLOS Pathogens

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    seeding potencyprion infectivitybrain structuressCJD prionsseeding activityprion strainsStructural characteristicsCDIsynchrotron-generated hydroxyl radicalsprion particlesEuropium-labeled antibodiesstructure-specific mannersolvent-exposed domains drive repli...iatrogenic transmissibilityCreutzfeldt-Jakob diseasesurface domainsMMVV 2 prionsprion diseasesynchrotron hydroxylMSseeding ratepropagation rate

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