pone.0249239.s001.tif (718.11 kB)
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posted on 2021-04-01, 10:28 authored by Jason A. West, Anastasia Tsakmaki, Soumitra S. Ghosh, David G. Parkes, Rikke V. Grønlund, Philip J. Pedersen, David Maggs, Harith Rajagopalan, Gavin A. BewickRepresentative concentration response curves for stimulation of cAMP accumulation by GIPA-1 (A) and GIPA-2 (B) in CHO-K1 cells expressing mouse GIPR, showing that neither is acting as partial agonist.
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GIP receptor antagonismGLP 1 agonist uncoversGIPR peptide antagonistsOGTTbenefitChronic administration studiesglucose-dependent insulinotropic po...plasma insulin concentrationsChronic peptide-based GIP receptor ...agonism Combinatorial gut hormone t...fasting blood glucoseglucose tolerance testglucose toleranceDIOGIPA -2GIPR antagonistinsulin sensitizing effects
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