pgen.1010540.g008.tif (297.79 kB)
S-gene Manhattan plot.
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posted on 2022-12-12, 18:38 authored by Martin Jankowiak, Fritz H. Obermeyer, Jacob E. LemieuxView of the 1237 amino acids of the S protein, annotated by structure [47]; many top-scoring mutations are located in the N-terminal domain (NTD), receptor-binding domain (RBD), and furin cleavage (FC) site. Regions containing the fusion peptide (FP), heptad repeat (HR) 1 and 2, transmembrane domain (TM), and C-terminal domain (CTD) are also annotated.
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relative growth ratespivotal role playedpairwise interaction effectsallele frequency spacescalable probabilistic methodless well characterizedidentify numerous mutations9 million sarsinferring selection effectsdifferential viral fitnessselection actsviral lineagesviral evolutionxlink ">vaccination statusunprecedented viewspike proteinsequence millionsnucleocapsid proteinsn501 residuelasting vaccinesincrease fitnessidentifying fitnessglobal effortgenetic determinantsdiffusion approximationdeveloping effectivebvas ),baseline modelassociated mutationsapply bvasanalyses point
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