pone.0279229.g005.tif (1.12 MB)
Results of scenario analyses.
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posted on 2022-12-20, 18:32 authored by Benjamin Ruban-Fell, George Attilakos, Tao Haskins-Coulter, Christopher Hyde, Jeanette Kusel, Anne Mackie, Oliver Rivero-Arias, Basky Thilaganathan, Nigel Thomson, Cristina Visintin, John MarshallAlternative Inputs Scenario: Incorporation of alternative inputs based on alternate literature values. VP Test Accuracy Scenario: Higher test sensitivity for TAS and TVS for VP. Structural Scenario 1: Removal of TAS for VP at 32 weeks. Structural Scenario 2: Combined IVF- and LLP-based pathway. Abbreviations: BL/S, bilobed or succenturiate; IVF, in vitro fertilisation; LLP, low-lying placenta; TAS, transabdominal sonography; TVS, transvaginal sonography; UKOSS, UK Obstetric Surveillance System; VCI, velamentous cord insertion; VP, vasa praevia.
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velamentous cord insertionrequiring minimal changesmodel results suggestmain outcome measuresexploratory modelling studyanalytic tree modelassociated perinatal mortalityassociated perinatal deathsavoiding vci overdetection6 %) vp50 vp diagnosestvs ), diagnosedvp pregnancies ),detect vasa praeviacurrent clinical practice1 %]), followedpregnancies ]; llp66 tvs referralsbased pathway resulted2 %]; llpvci detection occurredtvs occurredpregnancies diagnosedvasa praeviaperinatal deathvp leadingvp casesgreatest detectionbased pathwaytargeted llpscreening pathwayxlink ">vitro fertilisationunited kingdomundiagnosed casestransvaginal sonographysubstantial proportionrobust basisquality dataoverdetected caseslying placentaslowest proportionshypothetical cohorthighest proportionsfuture discussion5 %])1 %]);0 %]).
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