pgen.1010582.s001.tif (2.88 MB)
Resistance of cbf11Δ cells to oxidative stress partially depends on Atf1 and is specific for hydrogen peroxide.
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posted on 2023-01-10, 18:29 authored by Jarmila Princová, Clàudia Salat-Canela, Petr Daněk, Anna Marešová, Laura de Cubas, Jürg Bähler, José Ayté, Elena Hidalgo, Martin Převorovský(A-D) Growth curves of stress-related mutants in the presence or absence of the indicated concentrations of H2O2 in YES medium. The pyp1Δ and sty1Δ strains represent strongly resistant and strongly sensitive controls, respectively. (E) Survival and growth under superoxide stress of WT, cbf11Δ, cbf12Δ and cbf11Δ cbf12Δ cultures spotted on YES plates containing 125 μM menadione.
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main pathway respondingcorresponding gene promotersmst1 histone acetyltransferasesschizosaccharomyces pombe pap1 transcription factorshow increased expressionlocalized chromatin hyperacetylationdiv >< presponse gene expressionincreased cellular resistanceatf1 transcription factorconserved sty1 stressgene expressionincreased stressincreased acetylationhistone h3response mechanismsresponse genesregulating transcriptionmga2 cut6 cbf11 specific stresspsychiatric disordersperturbed fattyoxidative stressneurodegenerative diseasesmetabolic statelysine 9lipid metabolismgenes viafission yeastfas inhibitionepigenetic informationdirectly controlcertain metabolitesbecoming apparentalso operateacid metabolismacc /<
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